What special precautions should I follow?

Before taking alosetron,

• Tell  your doctor and pharmacist if you are allergic to alosetron or any other medications.
• Do  not take fluvoxamine (Luvox) while you are taking alosetron.
• Tell  your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and amiodarone (Cordarone, Pacerone); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend);aprepitant (Emend); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac);cyclosporine (Neoral, Sandimmune); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin);fluoroquinolone antibiotics including ciprofloxacin (Cipro), gatifloxacin (Tequin), levofloxacin (Levaquin), norfloxacin (Noroxin), ofloxacin (Floxin), others;fluoxetine (Prozac, Sarafem); hormonal contraceptives (birth control pills, implants, injections, rings, and patches); hydralazine (apresoline); isoniazid (INH, Nydrazid);lovastatin (Advicor, Altocor, Mevacor);certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz),delaviridine (Rescriptor); efavirenz (Sustiva);indinavir (Crixivan), lopinavir (in Kaletra),nelfinavir (Viracept), ritonavir (Norvir, in Kaletra),and saquinavir (Fortovase, Invirase);nefazodone; procainamide (Procanbid, Pronestyl);sertraline (Zoloft); telithromycin (Ketek); ticlopidine (Ticlid);troleandomycin (TAO);verapamil (Calan, Covera, Isoptin, Verelan); and zafirlukast (Accolate). Many other medications may also interact with alosetron, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• Tell  your doctor if you have or have ever had the conditions listed in the IMPORTANT WARNING section or any stomach or bowel problems, surgery to your stomach or bowels, or liver or kidney disease.
• Tell  your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking alosetron, call your doctor.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

What should I do if I forget a dose?   

Do not take a missed dose when you remember it. Skip the missed dose and take the next dose at the regularly scheduled time. Do not take a double dose to make up for a missed one.