Amifostine (Injection): Amifostine (am-i-FOS-teen) 

Protects  the kidneys from  harmful effects caused by some anti-cancer medicines (chemotherapy). Also  protects the saliva glands during some types  of radiation therapy. 

Brand Name(s): Ethyol 

There  may be other brand names  for this medicine.

When This Medicine Should Not Be Used: 

You should  not receive this medicine if you have had an allergic reaction to amifostine. 

How to Use This Medicine: 

Injectable

• Your doctor  will prescribe your exact dose and tell you how often it should  be given. This medicine is  given through a needle placed in one of your veins. 
• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand  all the risks and benefits. It is important for you to work closely  with your doctor during  your treatment. 
• You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. 
• This medicine is given before chemotherapy or radiation therapy. You may also receive other medicines to help prevent nausea and vomiting. 
• You will be watched closely for unwanted side effects while you are receiving this medicine. 
• Drink plenty of fluids during the 24 hours before receiving this medicine. 

Drugs and Foods to Avoid: 

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products. 

• Make sure your doctor knows if you are using a diuretic ("water pill") or any medicines for high blood pressure. Some diuretics are furosemide, torsemide, Demadex®, and Lasix®. High blood pressure medicines include atenolol, hydrochlorothiazide (HCTZ), lisinopril, metoprolol, quinapril, Accupril®, Cozaar®, Diovan®, Lotrel®, Norvasc®, Toprol®, and Zestril®. 

Warnings While Using This Medicine: 

• Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have a history of high blood pressure, heart disease, stroke, or TIA (transient ischemic attack). 
• Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects. 
• Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments. 

Possible Side Effects While Using This Medicine: 

Call your doctor right away if you notice any of these side effects: 

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. 
• Blistering, peeling, red skin rash. 
• Chest pain. 
• Fast, slow, or uneven heartbeat. 
• Severe nausea or vomiting. 
• Sudden dizziness or lightheadedness. 

If you notice these less serious side effects, talk with your doctor: 

• Fever or chills. 
• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.