Side Effects of Amoxicillin 

Amoxicillin 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON  side effects persist or become bothersome when using Amoxicillin: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin/Clavulanate

All medicines  may cause side effects, but many people have no, or minor  side effects. Check with  your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin/Clavulanate: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin/Clavulanate: 
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures;  severe diarrhea; stomach pain  or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin Capsules 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin Capsules: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin Capsules: 
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea;  stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin/Clavulanate Chewable Tablets 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin/Clavulanate Chewable Tablets: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin/Clavulanate Chewable Tablets: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin Chewable Tablets 

All medicines may cause  side effects,  but many people have no, or minor side effects. Check with your doctor  if any of these most COMMON side effects persist or become bothersome when using Amoxicillin Chewable Tablets: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin Chewable Tablets: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures;  severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the  skin or eyes. 

Amoxicillin Drops 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin Drops: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin Drops: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation;  yellowing of the skin or eyes.

Amoxicillin Extended-Release Tablets 

All medicines may cause side effects, but many people have no,  or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin Extended-Release Tablets: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin Extended-Release Tablets: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; white patches on the mouth or tongue; yellowing of the  skin or eyes. 

Amoxicillin/Clavulanate Extended-Release Tablets 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin/Clavulanate Extended-Release Tablets: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin/Clavulanate Extended-Release Tablets: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling  of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin/Clavulanate Suspension 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin/Clavulanate Suspension: 

Diaper rash; diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin/Clavulanate Suspension: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; white patches in the mouth; yellowing of the skin or eyes. 

Amoxicillin Suspension 

All medicines  may cause side effects, but many people have no, or minor side  effects. Check with  your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin Suspension: 

Diarrhea; nausea; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin Suspension: 
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps;  unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes. 

Amoxicillin/Clarithromycin/Lansoprazole Therapy Pack 

All medicines may cause side effects, but many people have no,  or minor side effects. Check with  your doctor if any of these most COMMON side effects persist or become bothersome when using Amoxicillin/Clarithromycin/Lansoprazole Therapy Pack: 

Changes in taste; diarrhea; dizziness; dry mouth; headache. 

Seek medical attention right away if any of these SEVERE side effects occur when using Amoxicillin/Clarithromycin/Lansoprazole Therapy Pack: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; pain, swelling, sores, or white patches in the mouth; red, swollen, or blistered skin; severe diarrhea; severe stomach pain or cramps; vaginal discharge, pain, or itching. 

Amoxicillin Side Effects - for the Professional 

Amoxicillin 

As with other penicillins, it  may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with  a history of allergy, asthma, hay fever, or urticaria. The following adverse reactions have been reported as associated with the use of penicillins: 

Infections and Infestations
 
Mucocutaneous candidiasis. 

Gastrointestinal
 
Nausea, vomiting, diarrhea, black hairy tongue, and hemorrhagic/pseudomembranous colitis.
 
Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. 

Hypersensitivity Reactions 

Anaphylaxis
  
Serum sickness–like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported. 

NOTE:  These hypersensitivity reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, Amoxicillin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only  to Amoxicillin therapy. 

Liver
 
A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted, but  the significance of this finding is unknown. Hepatic dysfunction including cholestatic jaundice, hepatic cholestasis  and acute cytolytic hepatitis has been reported. 

Renal
 
Crystalluria has also been reported. 

Hemic and Lymphatic Systems
 
Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. 

Central Nervous System
 
Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported rarely. 

Miscellaneous
 
Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases. 

Combination Therapy with Clarithromycin and Lansoprazole
 
In clinical trials using combination therapy with Amoxicillin plus clarithromycin and lansoprazole, and Amoxicillin plus lansoprazole, no adverse reactions peculiar to these drug combinations were observed.  Adverse reactions that have occurred have been limited to those that had been previously reported with Amoxicillin, clarithromycin, or lansoprazole. 

Triple Therapy 

Amoxicillin/Clarithromycin/Lansoprazole
 
The most frequently reported adverse events for patients who received triple therapy were diarrhea (7%), headache (6%), and taste perversion (5%). No treatment-emergent adverse events were observed at significantly higher rates with triple therapy than with any dual therapy regimen. 

Dual Therapy
 
Amoxicillin/Lansoprazole
 
The most frequently reported adverse events for patients who received Amoxicillin three times daily plus lansoprazole three times daily dual therapy were diarrhea (8%) and headache (7%). No treatment-emergent adverse events were observed at significantly higher rates with Amoxicillin three times daily plus lansoprazole three times daily dual therapy than with lansoprazole alone.