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Azithromycin
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Azithromycin

What  is the most important information I should know about azithromycin? 
 
Do not use azithromycin if you have ever had an allergic reaction to
  this medicine or similar drugs such as erythromycin (E-Mycin, Ery-Tab, E.E.S.), clarithromycin (Biaxin), telithromycin (Ketek), or troleandomycin (Tao). 

There are many other medicines that can interact with azithromycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new  medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. 
 
Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Azithromycin will not treat a viral infection such as the common cold or flu.
 
Take azithromycin on an empty stomach 1 hour before or 2 hours after meals.
 

Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take azithromycin. This includes Rolaids, Maalox, Mylanta, Milk of Magnesia, Pepcid Complete, and others. These antacids can make azithromycin less effective when taken at the same time. 

What is azithromycin? 

Azithromycin is in a group of drugs called macrolide antibiotics. Azithromycin fights bacteria in the body. 

Azithromycin is used to treat many different types of  infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and  sexually transmitted diseases. 

Azithromycin may also be used  for other purposes not listed in this medication guide. 

What  should I discuss with my healthcare provider before taking azithromycin? 
 
Do not use azithromycin if you have ever had an allergic reaction to
  this medicine or similar drugs such as erythromycin (E-Mycin, Ery-Tab, E.E.S.), clarithromycin (Biaxin), telithromycin (Ketek), or troleandomycin (Tao). 

Before taking azithromycin, tell your doctor if you have: 

  • liver disease; 
  • kidney disease; 
  • a heart rhythm disorder; or 
  • a history of Long QT syndrome. 
If you have any of these conditions, you may need  a dose adjustment or special tests to safely take this medication. 

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
 
 
It is not known whether azithromycin passes into breast milk  or if it could harm  a nursing baby. Do not  take this medication without telling  your doctor if  you are breast-feeding a baby. 

How should I take azithromycin? 

Take this medication  exactly as it was prescribed for you.  Do not take the medication in larger amounts,  or take it for longer than recommended by your doctor. The dose and length  of treatment  with azithromycin may not be  the same for every type  of infection.
 
 
  • Take each tablet or capsule  with a full glass (8 ounces)  of water.
  • To use the oral suspension single dose packet: Open the packet and pour the medicine into 2 ounces of water. Stir this mixture and drink all of it right away. To make sure  you get the entire dose, add a little more water  to the same glass, swirl gently and drink right away. 
  • Azithromycin capsules must be taken on an empty stomach. Take the capsule at least 1 hour before or 2 hours after eating a meal. 
  • Azithromycin tablets  or powder oral suspension may be taken with or without food. Take  the tablet or oral suspension with food if the medicine upsets  your stomach.
  • Shake the oral suspension (liquid) well just before you measure a dose. To  be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device,  ask your pharmacist for one. 
  • Take  this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Azithromycin will not treat a viral infection such as the common cold or flu. 
  • Store  this medication at room temperature away from moisture  and heat.  Throw away any unused  liquid medicine after 10 days.
What happens if I miss a dose? 

Take the missed dose as soon as you remember. If it is almost time for  your next dose, skip the missed dose and take the medicine  at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. 

What happens if  I overdose? 
 
Seek emergency medical attention if you think you have used too much of this medicine. 

Overdose symptoms may include nausea, vomiting, diarrhea, and stomach discomfort. 

What should I avoid while taking azithromycin? 
 
Do not take antacids that contain aluminum or magnesium within 2 hours before or after you take azithromycin. This includes Rolaids, Maalox, Mylanta, Milk of Magnesia, Pepcid Complete, and others. These antacids can make azithromycin less effective when taken at the same time.
 

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call  your doctor. Do not use any medicine to stop  the diarrhea unless your  doctor has told you to.
 
Avoid exposure
  to sunlight or artificial UV rays (sunlamps or tanning beds). Azithromycin can make  your skin more sensitive  to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. 

What are the possible side effects of azithromycin? 
 
Get emergency medical help if
  you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of  your face, lips, tongue, or throat.
 
Call your doctor at once if you have a serious side effect such as:
 
  • diarrhea that is watery or bloody; 
  • chest pain, uneven heartbeats; 
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or 
  • Fever, sore throat, and headache with a severe blistering, peeling, and red skin rash. 
Less serious side effects may include: 
  • mild nausea, vomiting, diarrhea, constipation, or stomach pain; 
  • dizziness, tired feeling, or headache; 
  • nervous feeling, sleep problems (insomnia); 
  • vaginal itching or discharge; 
  • mild itching or skin rash; 
  • ringing in your ears, problems with hearing; or 
  • Decreased sense of taste or smell. 
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. 

What other drugs will affect azithromycin? 

Many drugs can interact with azithromycin. Below is just a partial list. Tell your doctor if you are using: 
  • digoxin (Lanoxin, Lanoxicaps); 
  • carbamazepine (Carbatrol, Tegretol); 
  • cyclosporine (Neoral, Sandimmune); 
  • phenytoin (Dilantin); 
  • pimozide (Orap); 
  • theophylline (Theo-Dur, Theolair, Theochron); 
  • warfarin (Coumadin);
  • another antibiotic, especially clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S, Ery-Tab); 
  • a calcium channel blocker such as diltiazem (Cartia XT, Diltiazem, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), verapamil (Calan, Covera-HS); 
  • cholesterol-lowering medicines such as lovastatin (Mevacor), atorvastatin (Lipitor), or simvastatin (Zocor); 
  • ergot medicine such as methysergide (Sansert), ergotamine (Ergostat, Medihaler, Cafergot, Ercaf, Wigraine), dihydroergotamine mesylate (D.H.E., Migranal Nasal Spray); 
  • HIV medicines such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase); or 
There are many other medicines that can interact with azithromycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. 

Where can I get more information? 

Your pharmacist can provide more information about azithromycin. 

Original Author

Healthocrates Staff

Physician/Scientist

James Minor

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Notes:
DrJMinor
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EditText of this page (last edited December 12, 2009)