Warnings and  precautions before  taking Baclofen : 

• Abrupt discontinuation has resulted in high fever, altered mental status, exaggerated rebound spasticity,  and muscle rigidity that in rare cases advances  to rhabdomyolysis, multiple organ system failure and death. 
• The safety  and efficay of Baclofen medicine have not been studied in children  and adolescents. 
• Give special attention to patients at apparent risk (eg, spinal cord injuries at T-6  or above, communication difficulties, history of withdrawal symptoms from oral  or intrathecal baclofen. 
• Advise women before using Baclofen to inform health care provider  if pregnant, planning to become pregnant, or breastfeeding  while taking Baclofen. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery. 
• Warn patient before using Baclofen not to discontinue medication abruptly. Explain  that hallucinations or seizures  may occur. 
• Instruct patient before using Baclofen  to report the following symptoms to health care provider: dizziness, nausea, hypotension, urinary frequency, retention, painful urination, headache, seizures, and weakness. 

What if Overdose of Baclofen? 

If you think you or anyone else taken overdose of Baclofen, immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Vomiting, muscular hypotonia, muscle twitching, drowsiness, accommodation disorders, coma, respiratory depression, seizures (oral); drowsiness, lightheadedness, dizziness, somnolence, respiratory depression, seizures (intrathecal) are may be the overdose symptoms of Baclofen. 

What if Missed Dose of Baclofen? 

If you miss a dose of Baclofenmedicine and you remember within an hour or so, take  the dose immediately. If  you do not  remember until later,  skip the dose you missed  and go back to  your regular schedule. Do not double doses. 

Storage Conditions  for Baclofen: 

Store at room temperature in tightly closed container. Have resuscitation equipment available during trial drug period if intrathecal administration is considered. Patient must have positive response to trial of intrathecal medication before use of implantable pump. 

Notes: DrJMinor

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EditText of this page (last edited December 15, 2009)