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 Benign Tumors
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James Minor
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Benign Tumor 

A benign tumor is a tumor that lacks all three of the malignant properties of a cancer. Thus, by definition, a benign tumor does not grow in an unlimited, aggressive manner, does not invade surrounding tissues, and does not metastasize. Common examples of benign  tumors include moles and uterine fibroids. 

The term "benign" implies a mild and nonprogressive disease, and indeed, many kinds of benign tumors are harmless to the health. However, some neoplasms which are defined as 'benign tumors' because they lack the invasive properties of a cancer, may still produce negative health effects. Examples of this include tumors which produce a "mass effect" (compression of vital organs such as blood vessels), or "functional" tumors of endocrine tissues, which may overproduce certain hormones (examples include thyroid adenomas, adrenocortical adenomas, and pituitary adenomas). 

Benign tumors typically  are encapsulated, which inhibits their ability to behave  in a malignant manner. Nonetheless, many types of benign tumors have the potential to become malignant and some types, such as teratoma,  are notorious for this. 

Classification 

The term "tumor" literally means "swelling", and the broadest definition  of "benign tumor" encompasses all abnormal tissue masses which are not cancers. In practice, most of these entities are neoplasms, meaning that they contain a discrete population of  cells which proliferate in an independent manner, usually as the result of acquired genetic abnormalities. Entities which may be referred to as "tumors" but are non-neoplastic include developmental abnormalities, such as hamartomas  and ectopic rests (normal tissue in an anatomically abnormal location). 

Benign neoplasms are typically composed of  cells which bear a strong resemblance to a normal cell type in their organ of origin. These tumors are named for the cell or tissue type from which  they originate, followed by the suffix "-oma" (but not -carcinoma, -sarcoma, or -blastoma, which are generally cancers). For example, a lipoma is a common benign tumor of fat  cells (lipocytes), and  a chondroma  is a benign tumor of cartilage-forming cells (chondrocytes). Adenomas are benign tumors of gland-forming cells, and are usually specified further by their cell  or organ of origin, as in hepatic adenoma (a benign tumor of hepatocytes, or liver cells). There are a few cancers with 'benign-sounding' names which have been retained for historical reasons, including melanoma (a cancer of pigmented skin cells, or melanocytes) and seminoma (a cancer of male reproductive cells). 

In some cases, certain "benign"  tumors may later give rise to malignant cancers, which result from additional genetic changes in a subpopulation of the tumor's neoplastic cells. A prominent example of this phenomenon is the tubular adenoma, a common type of colon polyp which is an important precursor to colon  cancer. The cells in tubular adenomas, like most  tumors which frequently progress to cancer, show certain abnormalities of cell maturation and appearance collectively known as dysplasia. These cellular abnormalities are not seen  in benign tumors that rarely  or never turn cancerous, but are seen in  other pre-cancerous tissue abnormalities which do not form discrete masses, such as pre-cancerous lesions  of the uterine cervix. Some authorities prefer to refer to dysplastic tumors as "pre-malignant", and reserve the term "benign" for tumors which rarely or never give rise to cancer. 

Signs and symptoms 

Benign tumors are very diverse, and may  be asymptomatic or may cause specific symptoms depending  on their anatomic location and tissue type. Symptoms or pathological effects of some benign tumors may include: 

  • Bleeding or occult blood loss causing anemia 
  • Pressure causing pain or dysfunction 
  • Cosmetic changes 
  • Itching 
  • Hormonal syndromes' resulting from hormones secreted by the tumor 
  • Obstruction, e.g., of the intestines 
  • Compression of blood vessels or  vital organs 
Treatment 

Many benign tumors do not need to be treated at all. If a benign tumor is causing symptoms, presents a health risk, or causes a cosmetic concern for the patient, surgery is usually the most effective approach. Most benign tumors do not respond to chemotherapy or radiation therapy, although there are exceptions. 

Notes:
DrJMinor
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EditText of this page (last edited December 21, 2009)

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