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 Desipramine
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MKSchlossbergMD
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Desipramine

Dosage Forms 

  • This medicine is available as a tablet. 
Pharmacologic Category 
  • Antidepressant, Tricyclic (Secondary Amine) 
What key warnings should I know  about before giving  this medicine  to my child? 
  • Watch  your child closely for signs  or symptoms of depression or a desire to harm him/herself. These feelings  may last until  the depression  is completely treated. Ask  your child to talk with you  if he/she is  planning to harm him/herself. Take  your child to  the nearest emergency room if he/she wants  to harm him/herself. Talk with healthcare provider. 
  • Sometimes depression can worsen after starting treatment. Watch your child closely for signs of this. Talk with  healthcare provider now if  you notice this change. 
  • This medicine does not mix well with many medicines. Serious reactions may occur. Check  all medicines  with child's healthcare provider. 
  • Please read  the medication guide. 
Is it safe for my child to take this medicine? 
  • Not if  your child has  an allergy  to desipramine  or any other part  of this medicine. 
  • Be sure to let healthcare provider  know if your child has any allergies  or reactions  to medicine, food preservatives,  or dyes. Make sure  to tell  about the allergy  and how it affected  your child. This includes telling about rash; hives; itching; shortness  of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved. 
Why does my child need this medicine? 
  • This medicine is used to prevent bedwetting. 
  • This medicine  is used to prevent migraine headaches. 
  • This medicine is used to relieve chronic pain conditions. 
  • This medicine is used to treat anxiety. 
  • This medicine is used to treat depression. 
  • This medicine is used to treat eating disorders. 
  • This medicine is used to treat obsessive-compulsive disorder. 
  • This medicine  is used to treat panic attacks. 
How does this medicine work? 
  • Desipramine increases chemicals  in the brain. 
How is this medicine given? 
  • Give this medicine at bedtime if it causes sleepiness. 
  • Give this medicine with or without food. Give with food if it causes an upset stomach. 
  • Tablet may be crushed and mixed with food or liquid. 
How long does this medicine take to work? 
  • Your child may start feeling better several weeks after starting this medicine. 
  • In depression, sleep  and appetite may improve quickly. Other depressive symptoms may take up  to 4-6 weeks to improve. 
What  do I do if my child misses a dose? (does  not apply to patients in the hospital) 
  • Give  a missed dose as soon as possible. 
  • If it is almost time  for the next dose, skip the missed dose and return  to your child's regular schedule. 
  • Do not give a double dose or extra doses. 
  • Do not change dose or  stop your child's medicine. Talk with healthcare provider. 
What safety measures should I take while my child is using this medicine? 
  • If your child has been  taking this medicine for several weeks, talk with healthcare provider before stopping. You  may want to gradually withdraw this medicine.
  • Your child may have certain heart tests before starting  this medicine. Talk with healthcare provider. 
  • If your child has a family history of heart disease, talk with healthcare provider. 
  • If your child has heart disease, talk with healthcare provider. 
  • If your child has seizures, talk with healthcare provider. 
  • If your child has an overactive thyroid, talk with healthcare provider. 
  • Check your child's medicines with healthcare provider. This medicine may not mix well with other medicines. 
  • Avoid giving your child other medicines and natural products that slow actions and reactions. 
  • Avoid giving your child grapefruit and grapefruit juice. 
  • This medicine may cause  your child to be less alert. Have your child avoid tasks  or activities that require alertness. These include playing (for example, riding a bicycle, rollerblading, contact sports) or using items that require concentration or coordination (for example, scissors, lawnmower, electric scooters, or toy cars). Your child's activities should be closely monitored until you see how this medicine affects him/her. School work may be more difficult  for your child to focus on and complete. 
  • Your child can get sunburned  more easily. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen; dress your child in protective clothing and encourage use of protective eyewear. 
  • Your child may have a higher risk of cavities. 
What are some possible side effects of  this medicine?
  • Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Have your child avoid tasks or activities that require alertness or clear vision until you see how this medicine affects him/her. 
  • Feeling dizzy. Rising slowly over several minutes from sitting or lying position is recommended. Children should be extra careful climbing stairs. 
  • Blurred vision. Have your child use caution when doing activities that require clear vision. 
  • Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative. 
  • Dry mouth. Frequent mouth care may help. Older children may suck hard, sugar-free candy. 
  • Unexpected excitement can rarely occur. 
What should I monitor? 
  • Change  in condition being treated. Is  it better, worse,  or about the same? 
  • For the occurrence of side effects. 
  • Take care of your child's teeth. See a dentist regularly. 
When should I call my child's healthcare provider? 
  • If any of this information causes you to be concerned, any of the common side effects occur, or if your child's symptoms do not improve after taking this medicine. 
  • If you suspect an  overdose, call your local poison control center or emergency department immediately. 
  • If your child shows signs  of a life-threatening reaction, call healthcare provider or emergency department immediately. These  include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat; or if your child exhibits any other unusual behavior. 
  • If your child is planning to harm him/herself. If the desire to harm him/herself increases. 
  • If your child shows signs of severe dizziness or passes out. 
  • If your child has significant change in thinking clearly and logically. 
  • If your child is feeling extremely nervous and excitable. 
  • If your child is feeling extremely tired or weak. 
  • If your child develops  a rash. 
  • No improvement in condition or if you believe your child's condition is worse. 
How should I store and/or dispose of this medicine? 
  • Store at room temperature. 
  • Protect from light. 
  • Protect from moisture. Do not store  in a bathroom or kitchen. 
General statements 
  • If your child has a life-threatening allergy, he/she should wear an allergy identification bracelet at all times. 
  • This medicine is available by prescription only. If there are refills, contact your pharmacy. If no refills remain, you may need to contact your child's healthcare provider. 
  • This medicine  should be thrown out when your child no longer needs it or if the medicine becomes outdated. 
  • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag. 
  • Do not share your child's medicine with others and do not give anyone else's medicine to your child. 
  • Keep all medicine out of the reach of children and pets. 
  • Many medications interact with other medications.  Keep a list of  all your child's medicines (prescription, natural products, supplements, vitamins, over-the-counter)  with you. Give this list to  your child's healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant). 
  • Call  your doctor for medical advice  about side effects. You may report side effects to FDA 
  • Talk with your child's healthcare provider before giving him/her any new medicine, including over-the-counter, natural products, or vitamins. 
  • Medicine can be dangerous if used incorrectly. Follow directions given by healthcare provider. 

Notes:
Dr. M. Kristine Schlossberg
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EditText of this page (last edited March 2, 2010)

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