Diclofenac And Misoprostol (Arthrotec)

Diclofenac/Misoprostol is used for: 

Treating joint swelling, pain,  and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who  are at a high risk of developing NSAID-induced ulcers  or their complications. It may also be used for other conditions as determined by  your doctor. 

Diclofenac/Misoprostol  is an NSAID  and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach  and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins  that cause pain  and inflammation, relieving joint pain. 

Do NOT use Diclofenac/Misoprostol if:

• you are allergic to any ingredient in Diclofenac/Misoprostol  or other prostaglandins 
• you are pregnant 
• you  have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in  the nose, dizziness) to aspirin  or an NSAID (eg, ibuprofen, naproxen, celecoxib) 
• you  have recently had or will be  having bypass heart surgery 
• you have liver problems (eg, hepatic porphyria) 

Contact your doctor  or health care provider right away if any of these apply to you.
Before using Diclofenac/Misoprostol : 

Some medical conditions  may interact with Diclofenac/Misoprostol .  Tell your doctor or pharmacist  if you have any  medical conditions, especially  if any of the following apply to you: 

• if you are pregnant, planning to become pregnant,  or are breast-feeding 
• if you are taking any prescription or nonprescription medicine, herbal preparation,  or dietary supplement
• if you have allergies to medicines, foods, or other substances 
• if  you have  a history  of kidney  or liver problems, diabetes,  or stomach or bowel problems (eg, bleeding, perforation, ulcers) 
• if you have a history  of swelling or fluid buildup, seizures, lupus, asthma, or growths in  the nose (nasal polyps) 
• if you have high blood pressure, blood problems (eg, anemia, porphyria, low blood platelets),  bleeding or clotting problems, heart problems (eg, heart failure), blood vessel disease,  or inflammatory bowel disease, seizures, or if  you are at risk for  any of these diseases 
• if  you are dehydrated or if you drink alcohol, or have a history of alcohol abuse,  or smoke 

Some MEDICINES MAY INTERACT with Diclofenac/Misoprostol . Tell  your health care provider  if you are taking  any other medicines, especially any of the following: 

• Anticoagulants (eg, warfarin), heparin, aspirin, clopidogrel, rivaroxaban,  or selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, paroxetine) because  the risk of bleeding may  be increased
• Oral diabetic medicines (eg, glipizide) or insulin because  the risk  of high or low blood sugar may be increased 
• Quinolone antibiotics (eg, levofloxacin) because  the risk of seizures  may be increased 
• Probenecid because  it may increase  the risk  of Diclofenac/Misoprostol 's side effects 
• Cyclosporine, digoxin, lithium, methotrexate, or tenofovir because  the risk  of their side effects  may be increased by Diclofenac/Misoprostol 
• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) and diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac/Misoprostol 

This may not be  a complete list  of all interactions that may occur. Ask your health care provider if Diclofenac/Misoprostol may interact with  other medicines  that you take. Check with  your health care provider before  you start, stop, or change the dose  of any medicine. 

Notes: FCbinderMD

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EditText of this page (last edited March 31, 2010)