Dihydroergotamine Side Effects 

Dihydroergotamine:

All medicines  may cause side effects, but many people have no, or minor, side  effects. Check with  your doctor if any of these most COMMON side effects persist  or become bothersome when using Dihydroergotamine: 

Abnormal skin sensations; anxiety; diarrhea; dizziness; flushing; headache; increased sweating; nausea; vomiting. 

Seek medical attention right away if any  of these SEVERE side effects  occur when using Dihydroergotamine: 

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips,  or tongue); chest pain; difficulty breathing; itching; muscle  pain or weakness  in the arms and legs; numbness, coldness, loss of color,  or tingling  in the fingers and toes; swelling; swelling or itching at the injection site; temporary speeding or slowing of the heart rate. 

Dihydroergotamine Spray 

All medicines may cause  side effects, but many people have no, or minor, side effects. Check with  your doctor

if any of these most COMMON side effects persist  or become bothersome when using Dihydroergotamine Spray: 

Burning sensation; changes  in taste; diarrhea; dizziness; drowsiness; dry mouth; hot flashes; irritation; nasal congestion or dryness; nasal discharge; nausea; pain; reaction at the application site; runny nose; sinus inflammation; sore nose or throat; stiffness; tiredness; vomiting; weakness. 

Seek medical attention right away if any of these SEVERE side effects occur when using Dihydroergotamine Spray: 

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal skin sensations; chest pain; itching;  muscle pain or weakness  in the arms and legs; numbness, coldness, loss of color, or tingling  in the fingers  and toes; swelling; temporary  speeding or slowing of the heart rate.

Side Effects by Body System 

Gastrointestinal
Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported to occur commonly. 

The most frequent side effect with the use of intravenous dihydroergotamine is nausea. Following intramuscular or intranasal administration, the incidence of nausea is low. 

Other
Other side effects including arterial spasm, sometimes with resulting limb necrosis, have been reported rarely. The incidence is believed to be about 1 to 3 per 100,000 patients treated for thromboprophylaxis. 

Musculoskeletal
Musculoskeletal side effects including muscle cramps and weakness have been reported. 

Nervous system 
Nervous system side effects including drowsiness, restlessness, cerebral arteriopathy, and paresthesias have been reported. 

Local
Local side effects including pain, burning, itching, edemas, and hematomas at the site of parenteral administration have been reported to occur commonly. 

Cardiovascular
Cardiovascular  side effects including hypertension, tachycardia, bradycardia, precordial distress, and chest pain  have been reported. Myocardial ischemia and myocardial infarction have been reported rarely. 

Respiratory
Respiratory  side effects including pleural fibrosis have been reported following long-term high dose treatment. 

Renal
Renal side effect including retroperitoneal fibrosis has been reported following long-term high dose treatment.