Enalapril/Felodipine

Enalapril/Felodipine is used for: 

Treating high blood pressure. It may also be used for other conditions as determined by your doctor. 

Enalapril/Felodipine is an angiotensin-converting enzyme (ACE) inhibitor and calcium channel blocker combination. It works by relaxing blood vessels, which helps to lower blood pressure and decrease the workload of the heart. 

Do NOT use Enalapril/Felodipine if: 

• you are allergic to any ingredient in Enalapril/Felodipine or similar medicines (eg, captopril, lisinopril) 
• you are pregnant
• you are  taking dextran sulfate or a potassium-sparing diuretic (eg, amiloride) 

• if you are pregnant, planning to become pregnant, or are breast-feeding 
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement 
• if you have allergies to medicines, foods, or other substances 
• if you have or have a history of liver or kidney problems or have had a kidney transplant 
• if you are receiving dialysis 
• if you have bone marrow suppression, low  blood counts, low  blood sodium, high blood potassium,  the blood disease porphyria, lupus, scleroderma, or a collagen vascular disease 
• if you  have narrowing or hardening of the arteries of the brain or heart, chest pain, slow heartbeat or  other heart problems,  or breathing problems 

• Azole antifungals (eg, ketoconazole), cimetidine, diuretics (eg, furosemide, hydrochlorothiazide), or erythromycin because side effects, including excessive decreases in blood pressure, dizziness, or fainting, may occur 
• Dextran sulfate because it may increase the risk of allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) and lightheadedness upon standing 
• Oral diabetes  medicine (eg, glyburide) because side effects, including a low blood sugar level (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may  be increased by Enalapril/Felodipine 
• Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur 
• Potassium-sparing diuretics (eg, amiloride) or potassium supplements may cause high blood potassium levels (eg, abnormal skin sensations of the arms and legs, confusion, heaviness of the limbs, listlessness, slow or irregular heartbeat, stopping of the heart) when used with Enalapril/Felodipine 
• Lithium, macrolide immunosuppressives (eg, tacrolimus), or thiopurines (eg, azathioprine) because the risk  of serious side effects may be increased by Enalapril/Felodipine 
• Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, indomethacin) because they may decrease Enalapril/Felodipine 's effectiveness 

• Use Enalapril/Felodipine as directed  by your doctor. Check the label on the medicine for exact dosing instructions. 
• Take Enalapril/Felodipine by mouth with  or without food. If stomach upset occurs, take with food to reduce stomach irritation. 
• Swallow Enalapril/Felodipine whole.  Do not break, crush, or chew before swallowing. 
• Eating grapefruit or drinking grapefruit juice may affect  the amount of Enalapril/Felodipine in  your blood. Talk with  your doctor before including grapefruit  or grapefruit juice in your diet. 
• If  you miss a dose of Enalapril/Felodipine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.  Do not take 2 doses at once. 
• Ask your health care provider any questions you may have about how to use Enalapril/Felodipine . 

• Enalapril/Felodipine may cause dizziness  or lightheadedness. These effects may be worse if you  take it with alcohol or certain medicines. Use Enalapril/Felodipine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. 
• Check with  your doctor before you use a salt substitute or a product that has potassium in it. 
• Proper dental care is important while you are taking Enalapril/Felodipine . Brush  and floss your teeth and visit the dentist regularly. 
• Patients who take medicine for  high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure  to take your medicine  even if you may not  feel "normal." Tell your doctor if you develop any new symptoms. 
• Enalapril/Felodipine may  not work as well in black patients. They may also be at greater risk of side effects. Contact  your doctor if your symptoms do not improve or if they become worse. 
• Enalapril/Felodipine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Enalapril/Felodipine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time. 
• Tell your doctor or dentist that you take Enalapril/Felodipine before you receive any medical or dental care, emergency care, or surgery. 
• Lab tests, including liver function, kidney function, complete blood cell counts, and blood pressure, may be performed while you use Enalapril/Felodipine . These tests may be used to monitor your condition or check  for side effects. Be sure to keep all doctor and lab appointments. 
• Use Enalapril/Felodipine with caution  in the ELDERLY; they may be more sensitive to its effects. 
• Enalapril/Felodipine should be used with extreme caution in CHILDREN; safety  and effectiveness  in children have not been confirmed. 
• PREGNANCY and BREAST-FEEDING: Enalapril/Felodipine may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Enalapril/Felodipine  is found in breast milk. If you are  or will be breast-feeding while you use Enalapril/Felodipine , check with your doctor. 
• Discuss any possible risks  to your baby. 

Possible side effects  of Enalapril/Felodipine : 

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: 

Diarrhea; dizziness or lightheadedness when sitting up or standing; drowsiness; headache; nausea; persistent, dry cough; tiredness; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling  of the mouth, face, lips, or tongue); breast changes; changes in sexual function; chest pain; dry mouth; fainting; fast, slow, or irregular heartbeat; hoarseness; infection (fever, sore throat); infrequent urination; lethargy; muscle pain or cramps; muscle weakness; restlessness; thirst; unusual stomach pain; unusual swelling; weakness; yellowing of the skin or eyes. 

This  is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA  at 1-800-FDA-1088. You may also report side effects 

If OVERDOSE is suspected: 

Contact your local poison control center or emergency room immediately. Symptoms may include dizziness; lightheadedness, especially upon standing; weakness. 

Proper storage of Enalapril/Felodipine : 

Store Enalapril/Felodipine at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture,  and light. Do not store in  the bathroom. Keep Enalapril/Felodipine out of the reach of children  and away from pets. 

General information: 

• If you have any questions about Enalapril/Felodipine , please talk with your doctor, pharmacist, or other health care provider. 
• Enalapril/Felodipine is to be used only by the patient for whom it is prescribed.  Do not share it with other people. 
• If  your symptoms do not improve or if they become worse, check with  your doctor. 

This information is a summary only. It does not contain all information about Enalapril/Felodipine . If  you have questions about the medicine you are taking or would like more information, check with  your doctor, pharmacist, or other health care provider.