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 Esomeprazole (Nexium)
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What is esomeprazole (Nexium)? 

Esomeprazole decreases  the amount  of acid produced in the stomach.
Esomeprazole is used to treat symptoms of
  gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used  to promote healing of erosive esophagitis (damage  to your esophagus caused by stomach acid).
Esomeprazole
  may also be given  to prevent gastric ulcer caused  by infection  with helicobacter pylori (H. pylori),  or by the  use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Esomeprazole may also be used for other purposes not listed in
  this medication guide. 

What  are the possible side effects of esomeprazole (Nexium)? 

  • Get emergency medical help if you have any  of these signs of an allergic reaction: hives; difficulty breathing; swelling  of your face, lips, tongue, or throat. 
Less serious side effects may include: 
  • headache;
  • diarrhea;
  • nausea, stomach pain, gas, constipation; or 
  • dry mouth. 
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA 

What is the most important information I should know about esomeprazole (Nexium)? 
  • Do not use  this medication if you are allergic  to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox). 
  • Before taking this medication, tell your doctor if you have ever had liver  disease or any type of heart disease. You may need  a dose adjustment or special tests during treatment. 
  • Some conditions are treated with a combination  of esomeprazole  and antibiotics. To best  treat your condition, use all  of your  medications as directed by your doctor. Be sure  to read  the medication guide or patient instructions provided with each  of your medications. Do not change your doses or medication schedule without advice from your doctor. 
  • Take this medication  for the entire length  of time prescribed  by your doctor. Your symptoms may get better before your treatment is completed. 
  • Do not crush, break, or open a delayed-release capsule. Swallow  the pill whole. It is specially  made to release medicine slowly  in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. 
What should I discuss with my healthcare provider before taking esomeprazole (Nexium)? 
  • Do not use this medication if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox). 
  • Before taking this medication, tell your doctor if you have ever had liver disease or any type of heart disease. You may need a dose adjustment or special tests during treatment. 
  • Some conditions are treated with  a combination of esomeprazole  and antibiotics. To best treat your condition, use all of your medications  as directed by your doctor. Be sure  to read the medication guide or patient instructions provided  with each of your medications. Do not change your doses  or medication schedule without advice from your doctor. 
  • FDA pregnancy category B. This medication  is not expected  to be harmful to an unborn baby. Tell  your doctor if you are pregnant  or plan to become pregnant during treatment. 
  • It is  not known whether esomeprazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. 
How should I take esomeprazole (Nexium)? 
  • Take this medication  exactly as it was prescribed for you.  Do not take the medication in larger amounts,  or take it for longer than recommended by your doctor. Follow the directions on your prescription label. 
  • This medicine is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time. 
  • Take each dose with a full glass (8 ounces) of water. 
  • Esomeprazole should be taken at least one hour before a meal. 
  • Do not crush, break, or open a delayed-release capsule.  Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking  or opening  the pill would cause too much  of the drug to be released at  one time. 
  • You may open the delayed-release  capsule and sprinkle the medicine into a spoonful  of pudding or  applesauce to make swallowing easier. Swallow this  mixture right away without chewing.  Do not save the mixture  for later use. Discard  the empty capsule. 
  • Esomeprazole can be given through  a nasogastric (NG) feeding tube.  Open the capsule  and sprinkle the medicine into a 60-milliliter syringe. Mix in 50 milliliters of  water. Place  the plunger into the syringe and shake the mixture well. Make sure there are no medicine granules stuck in the tip of the syringe. Attach the syringe  to the NG tube and push  the plunger down to empty  the syringe into the tube. Then flush the tube with  more water to wash  the contents down. 
  • It is important  to use  esomeprazole regularly  to get the most benefit. Get your prescription refilled before  you run out  of medicine completely. 
  • Take this medication  for the entire length of time prescribed by  your doctor. Your symptoms  may get better before  your treatment is completed. 
  • Store esomeprazole at room temperature away from moisture  and heat. 
What happens if I miss a dose (Nexium)? 
Take  the missed dose as soon as you remember. If it  is almost time for  your next dose, skip  the missed dose and take the medicine  at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. 

What happens if I overdose (Nexium)? 
Seek emergency medical attention if you think you have used too much  of this medicine.
Overdose symptoms
  may include confusion, headache, drowsiness,  blurred vision,  fast heartbeat, nausea,  dry mouth, sweating, flushing, shortness of breath, tremor, loss of coordination, or seizure (convulsions). 

What should I avoid while taking esomeprazole (Nexium)? 
Follow  your doctor's instructions about  any restrictions on food, beverages, or activity while  you are using esomeprazole. 

What other drugs will affect esomeprazole (Nexium)? 

Before taking esomeprazole, tell your doctor if you are using any of the following drugs: 
  • clopidogrel (Plavix); 
  • digoxin (Lanoxin, Lanoxicaps); 
  • diazepam (Valium); 
  • ketoconazole (Nizoral); 
  • HIV or AIDS medication such as atazanavir (Reyataz), nelfinavir (Viracept), saquinavir (Invirase), and others; 
  • iron (Feosol, Mol-Iron, Fergon, Femiron, others); or 
  • a blood thinner such as warfarin (Coumadin). 
This list is not complete and there may be other drugs that can interact with esomeprazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. 

Where can I get more information? 
Your pharmacist can provide more information about esomeprazole. 

Notes:
FCbinderMD
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EditText of this page (last edited April 16, 2010)

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