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 Eye Cancer
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F.C. Binder
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Eye Cancer

  • Cancer  of the eye is rare in the United Kingdom. About 450 people get eye cancer each year.  Eye cancer is usually treated with surgery, radiotherapy or chemotherapy. 
  • Animation - How  cancer develops 
  • About  eye cancer
  • Symptoms  of eye cancer
  • Causes of eye cancer
  • Diagnosis of eye cancer 
  • Treatment of eye cancer
  • Questions  and answers 
  • Related topics 
  • Further information 
  • Sources 
How cancer develops 

About  eye cancer 

Eye cancer  is caused by an uncontrolled growth of cells in or around the eye. There  are several different types of eye cancer.

Cancer  that develops in  the eye is called intraocular cancer. Cancer  that develops outside  the eye is called extraocular cancer. 

Intraocular eye cancers 
  • Non-Hodgkin's lymphoma - this usually develops in lymph nodes (these are glands throughout  the body that are part  of the immune system). However, non-Hodgkin's lymphoma sometimes develops in the eye. 
  • Ocular melanoma - this usually develops in  the lining of the eyeball, the muscles  that focus the eye, the iris (the coloured part  of the eye) or  the inner surface of eyelids (conjunctiva). Melanoma is one of the most common types of intraocular  eye cancers. 
  • Retinoblastoma - this usually develops in the retina and  can affect one  or both eyes. It is often inherited  and develops  in young children, usually under five. Over nine out of 10 children with retinoblastoma are cured with  the right treatment. 
Extraocular eye cancers 
  • Basal cell carcinoma - this  is the most common type of skin cancer  in the UK. It often develops near your eye, especially on  the lower eyelid. It causes a small red growth on  the skin that often  has a rolled edge  to it. It doesn't usually spread  to other parts  of the body, but it can  affect surrounding tissue if it isn't treated. 
  • Squamous cell carcinoma - this usually develops on the surface  of the eyelid. 
  • Rhabdomyosarcoma - this is a very rare type  of eye cancer which develops in  the muscles that move the eye. It mostly affects children. 
  • Optic nerve tumours - rarely, a tumour can develop  in your optic nerve which connects your eye  to the brain. 
Secondary eye cancers 

Sometimes a cancer can spread to  the eye  from another part  of the body (called a secondary eye cancer). This is most likely to happen  in women with breast cancer, and in men with lung cancer. 

Symptoms of eye  cancer

Symptoms  of eye cancer vary depending on the type of  cancer and where it's located. 

Intraocular cancers such as ocular melanoma have no symptoms but  are usually detected in routine eye examinations. This is why it's important  to have an  eye test every two years.

Some eye cancers can cause symptoms including: 

  • partial or complete loss  of vision 
  • seeing flashing lights or spots 
  • a dark spot on your iris that's growing 
  • a visible lump on your eyelid with crusting or bleeding 
  • pain in or around the eye (rare) 
  • a bulging eye 
  • watery eyes 
Most children with  retinoblastoma look well, but parents may notice a squint or an odd looking pupil. The pupil may be white  in flash photography rather than showing  a red eye. 

Causes of eye cancer 

Doctors don't fully understand why  eye cancer develops. You may be more likely  to develop certain  types of eye cancer if you have: 
  • blue, grey or green eyes 
  • unusual brown spots on your eye 
  • lots  of unusually shaped or large moles (atypical mole syndrome) 
  • been out in  the sun too much without wearing sun protection such as sunglasses or a wide-brimmed hat 
  • a weakened immune system - people who have HIV/AIDS, or who are taking medicines that suppress the immune system, are more likely to develop lymphoma of the eye 
  • inherited genes - four in 10 children with retinoblastoma inherit a faulty gene from their parents 
Diagnosis of eye cancer

If your GP thinks  that you have cancer  of the eye, you will  usually be referred to your local hospital to be seen by a doctor who specialises  in eye conditions (an ophthalmologist). If  the ophthalmologist suspects you have eye cancer, he or she may refer you to a specialist centre for eye cancer. 

You may have  the following tests to confirm diagnosis. 
  • Eye examination - your doctor will shine a light into your eye and look inside  the eye using special hand-held instruments. You may  have drops put into your eyes which can affect your vision for a short while. 
  • Fluorescein angiography - a dye is injected into your arm which travels through your bloodstream to  the blood vessels  in the eyes where it shows up on photographs so your doctor can look at  the blood vessels in your eyes. 
  • Ultrasound scan - a small ultrasound sensor is moved over closed eyelids or on the skin around your eye with sound waves creating an image  of the inside  of your eye. 
  • CT or MRI scan - these may be done to check  the muscle and tissues  in and around your eye. 
  • Biopsy - using  a fine needle, a sample of the fluid inside your eye is taken (or, for suspected cancer  on the surface around your eye, a sample of tissue is taken)  and sent  to a laboratory  for diagnosis.
Treatment  of eye cancer 

Treatment depends on  the type  of eye cancer,  the size  and how far it has spread (staging)  and your general state  of health. There are three main treatments for eye cancer. 

Surgery

Surgery involves removing just  the affected tissue. Surgery  is usually enough to remove most tumours  of the eyelids. It's sometimes combined with radiotherapy for treating cancers  in the eye. 

Some types  of eye cancer,  such as melanoma of  the eye, can be treated with laser therapy (a high-energy beam  of light  is used to destroy the cancer cells). 

Occasionally, if the cancer affects  a large part of the eye, the whole eyeball may need to be removed (enucleation). You may feel upset  or worried  about how you will cope. The doctors and nurses looking after you will support and help you. An artificial (prosthetic) eyeball can be created  to match your remaining eye. 

Non-surgical treatments 
  • Radiotherapy - radiation is used to kill cancer cells. It is often used for treating melanoma of the eye. 
  • Chemotherapy - anti-cancer drugs  are used to destroy cancer cells. They are usually injected into  a vein but sometimes may be given as tablets. Chemotherapy can be effective for treating lymphoma of  the eye and retinoblastoma. It's  only used for melanoma of  the eye if other types of treatment haven't worked. 

Notes:
FCbinderMD
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EditText of this page (last edited April 25, 2010)

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