Fludarabine Phosphate

What is this medicine? 

FLUDARABINE (floo DARE  a been) is a chemotherapy drug. It interferes with  the growth of cancer cells. It is usually used to treat chronic lymphocytic leukemia (CLL).
 
This medicine may be used for other purposes; ask  your health care provider or pharmacist if you have questions. 

What should I tell my health care provider before I take this medicine? 

They need to know if  you have any of these conditions:

• infection (especially virus infection such as chickenpox or cold sores) 
• kidney disease 
• low blood counts like low platelets, red blood cells, white blood cells 
• an unusual or allergic reaction to fludarabine, other chemotherapy, other medicines, foods, dyes, or preservatives 
• pregnant or trying to get pregnant 
• breast-feeding 

How should I use this medicine? 

This  drug is given as an infusion  into a vein. It  is administered in a hospital or clinic by a specially trained health care professional. 

Talk  to your pediatrician regarding the use of this medicine in children. Special care may be needed. 

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. 

NOTE: This medicine is only  for you. Do not share this medicine with others. 

What may interact with this medicine? 

Do not take this medicine with any of the following medications:
pentostatin 

This medicine may also interact with the following medications: 

• medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim 
• vaccines 

Talk to  your doctor or health care professional before taking any of these medicines: 

• acetaminophen 
• aspirin 
• ibuprofen 
• naproxen 
• ketoprofen 

This list may not describe all possible interactions. Give your health care provider  a list of all  the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. 

Some items may interact with your medicine. 

What should I watch for while using this medicine? 

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy  cells as well as cancer cells. Report any side effects. Continue  your course  of treatment even though  you feel ill unless your doctor tells you to stop. 

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who  are sick. 

This medicine may increase  your risk  to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding. 

Be careful brushing  and flossing your teeth or using a toothpick because  you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine. 

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever. 

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential  for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking  this medicine. 

Men should inform their doctors if they wish to father a child. This  medicine may lower sperm counts. 

What side effects may I notice from receiving this medicine? 

Side effects that you should report  to your doctor or health care professional as soon as possible: 

• allergic reactions like skin rash, itching or hives, swelling  of the face, lips, or tongue 
• low blood counts -  this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk  for infections and bleeding. 
• signs  of infection - fever or chills, cough, sore throat, pain or difficulty passing urine 
• signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, nosebleeds 
• signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness 
• breathing problems 
• changes in hearing 
• changes in vision 
• confusion 
• dry cough 
• mouth sores 
• muscle weakness 
• pain, tingling, numbness in the hands or feet 
• swelling  of the ankles, feet, hands 
• trouble passing urine  or change in the amount of urine 
• yellowing of the eyes or skin 

Side effects that usually do not require medical attention (report to your doctor or health care professional if they  continue or are bothersome): 

• constipation
• diarrhea
• hair loss 
• loss of appetite 
• nausea, vomiting 
• trouble sleeping 

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA . 

Where should I keep my medicine? 

This drug is given in a hospital or clinic and will not be stored at home. 

Notes: FCbinderMD

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EditText of this page (last edited May 1, 2010)