Precautions  

Before taking hydroxyurea,

• tell your doctor and pharmacist if you are allergic to hydroxyurea, any other medications, or any of the inactive ingredients in hydroxyurea capsules. Ask your pharmacist for a list of the ingredients.
• tell your doctor if you are taking or have ever taken an interferon. (Interferons are a group of medications similar to substances produced by the body. They are used to treat diseases that involve the immune system such as certain types of cancer, hepatitis, multiple sclerosis, and genital warts. Brand names include Actimmune, Avonex, Betaseron, Rebif and others.) If you are taking or have ever taken an interferon, there is a greater chance that you will develop severe skin problems during your treatment with hydroxyurea. Ask your doctor or pharmacist if you are not sure if you are taking or have ever taken an interferon.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), especially didanosine (Videx) and stavudine (Zerit); probenecid;or sulfinpyrazone (Anturane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), if you are being treated with or have ever been treated with radiation therapy or cancer chemotherapy; if you have or have ever had kidney, or liver disease.
• tell your doctor if you are breast-feeding. You should not breastfeed during your treatment with hydroxyurea.
• your doctor may prescribe a folic acid supplement for you to take during your treatment with hydroxyurea. Take this medication exactly as directed.
• you should know that hydroxyurea may be harmful if it gets on the skin. People who are not taking hydroxyurea should avoid touching hydroxyurea capsules or the bottle that contains the capsules.Always wear disposable gloves when handling hydroxyurea capsules or bottles containing hydroxyurea capsules and wash your hands before and after you touch the bottle or capsules. If the powder from a capsule spills, wipe it up immediately with a damp disposable towel, place the towel in a closed container, such as a plastic bag and throw it away in a trash can that is out of the reach of children and pets.