Side effects

Hydroxyurea may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• vomiting
• diarrhea
• constipation
• drowsiness

Some side effects can be serious. If you experience any of the following symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately.

• rash
• purple, blue, or black discoloration of the skin or nails
• loss of feeling in one area of the body
• sores on the skin or in the mouth
• foul-smelling substance oozing from the skin.
• swelling of the hands, feet, ankles, or lower legs

Hydroxyurea may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/MedWatch/report.htm or by phone 1-800-332-1088.