Since the vast majority of KS patients in the United States are HIV-positive, taking measures to avoid HIV infection could prevent most cases of KS in this country.

During the early 1980s, blood transfusions were responsible for some HIV infections. As a result of improved HIV testing at blood banks, the risk has been almost eliminated.

Worldwide, most HIV infections are sexually transmitted as are infections with KSHV. Avoiding unprotected sexual contact with infected partners could prevent these infections.

Many public health workers recommend that a person not currently in a monogamous relationship with an HIV-negative partner should use a condom during any sexual contact.

Use of contaminated needles by intravenous (IV) drug abusers is the second most common source of HIV infection. Many different public health and law enforcement solutions have been recommended. As already noted, KS rarely occurs in people not infected with HIV.