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 Ketoconazole
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IMPORTANT WARNING:  

Ketoconazole may cause liver damage. Tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had liver disease. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, others); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor); isoniazid (INH, Nydrazid); methotrexate (Rheumatrex); niacin (nicotinic acid); or rifampin. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness, loss of appetite, upset stomach, vomiting, yellowing of the skin or eyes, dark yellow urine, pale stools, pain in the upper right part of the stomach, or flu-like symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to ketoconazole.

Do not take astemizole (Hismanal) (not available in the United States), cisapride (Propulsid), or terfenadine (Seldane) (not available in the United States) while you are taking ketoconazole.

Why is this medication prescribed?  

Ketoconazole is used to treat fungal infections. Ketoconazole is most often used to treat fungal infections that can spread to different parts of the body through the bloodstream such as yeast infections of the mouth, skin, urinary tract, and blood, and certain fungal infections that begin on the skin or in the lungs and can spread through the body. Ketoconazole is also used to treat fungal infections of the skin or nails that cannot be treated with other medications. Ketoconazole is in a class of antifungals called imidazoles. It works by slowing the growth of fungi that cause infection.

How should this medicine be used?  

Ketoconazole comes as a tablet to take by mouth. It is usually taken once a day. To help you remember to take ketoconazole, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ketoconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you have certain medical conditions, your doctor will tell you to take ketoconazole tablets dissolved in an acid solution. Your doctor will tell you exactly how to do this. Follow these directions carefully.

Your doctor will probably start you on an average dose of ketoconazole. Your doctor may increase your dose if your infection is very serious or your condition does not improve.

You may need to take ketoconazole for several weeks or months to cure your infection completely. Your doctor will probably order laboratory tests to be sure your infection has been treated. Continue to take ketoconazole until your doctor tells you that you should stop, even if you feel better. Do not stop taking ketoconazole without talking to your doctor. If you stop taking ketoconazole too soon, your infection may come back after a short time.

Other uses for this medicine  

Ketoconazole is also sometimes used to treat vaginal yeast infections, tinea versicolor (spots on skin caused by yeast), eumycetoma (a severe fungal skin infection that often affects the foot), leishmaniasis (a disease caused by the bite of an infected sand fly), prostate cancer (cancer that begins in a male reproductive organ), high blood levels of calcium in patients with certain conditions, Cushing's syndrome (high blood levels of a natural substance called cortisol), and excessive hair growth in women. Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What storage conditions are needed for this medicine?  

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose  

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?  

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking ketoconazole.

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription. If you still have symptoms of infection after you finish the ketoconazole, call your doctor.

Brand names  

  • Nizoral®

Notes:
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EditText of this page (last edited November 25, 2009)

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