Side Effects and Cautions

• In large amounts, licorice containing glycyrrhizin can cause high blood pressure, salt and water retention, and low potassium levels, which could lead to heart problems. DGL products are thought to cause fewer side effects.
• The safety of using licorice as a supplement for more than 4 to 6 weeks has not been thoroughly studied.
• Taking licorice together with diuretics (water pills) or other medicines that reduce the body's potassium levels could cause dangerously low potassium levels.
• People with heart disease or high blood pressure should be cautious about using licorice.
• When taken in large amounts, licorice can affect the body's levels of a hormone called cortisol and related steroid drugs, such as prednisone.
• Pregnant women should avoid using licorice as a supplement or consuming large amounts of licorice as food, as some research suggests it could increase the risk of preterm labor.
• Tell your health care providers about any herb or dietary supplement you are using, including licorice root. This helps to ensure safe and coordinated care.