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Main > Health Topics > Drug Therapy > Pain Relievers
Pain Relievers
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Pain relievers are medicines that reduce or relieve headaches, sore muscles, arthritis or any number of other aches and pains. There are many different pain medicines, and each one has advantages and risks. Some types of pain respond better to certain medicines than others. Each person may also have a slightly different response to a pain reliever.

Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medications: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve) and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs. If OTC medicines don't relieve your pain, your doctor may prescribe something stronger. Many NSAIDs are available at prescription doses. The most powerful pain relievers are narcotics. These drugs can have serious side effects. You must use them only under a doctor's supervision.

There are many things you can do to help ease pain. Pain relievers are just one part of a pain treatment plan.

How do pain relievers work?

Acetaminophen seems to relieve pain and reduce fever by working on the parts of the brain that receive pain messages and control the body’s temperature.

NSAIDs relieve pain and fever by reducing the level of hormone-like substances (called prostaglandins) that your body makes. These substances cause the feeling of pain by irritating your nerve endings. They also are part of the system that helps your body control its temperature.

What types of problems can OTC pain relievers help?

Acetaminophen and NSAIDs relieve pain caused by muscle aches and stiffness, and reduce fever. NSAIDs can also reduce inflammation (redness and swelling).

OTC pain relievers can be helpful in treating many types of pain, such as pain from arthritis, earaches, back pain, and pain after surgery. They can also treat pain from the flu (influenza) or a cold, sinusitis, strep throat or a sore throat. Children who may have the flu or chickenpox should not take aspirin because they are at higher risk to develop a condition called Reye’s Syndrome.

Acetaminophen can be a good choice for relieving headaches and other common aches and pains. It can be used safely by most people on a long-term basis for arthritis and other chronic painful conditions if pain is improved. Make sure you tell your doctor about any OTC medications you take regularly.

Ibuprofen is helpful for menstrual cramps and pain from inflammation (such as muscle sprains). If ibuprofen doesn’t work for you, naproxen and ketoprofen may be options.

Will an OTC pain reliever work as well as a prescription one?

For most people, OTC drugs are all they need to relieve pain or reduce fever. If an OTC drug doesn’t help your pain or fever, or if you’ve been taking an OTC drug for more than 10 days for pain or 3 days for fever, call your doctor. These may be signs that you have a more serious problem or need a prescription medicine.

What are some common side effects of OTC pain relievers?

Side effects from OTC pain relievers aren’t common for healthy adults who only use pain relievers once in a while. However, side effects can be a concern for people who use pain relievers often or who have health problems. If you have health problems or use pain relievers often, talk to your doctor.

Acetaminophen can be used safely by most people. It can cause liver damage in people who take very high doses or who already have abnormal liver function . To reduce your risk of liver problems, never take more than the recommended dose of acetaminophen. For adults and children older than 12, this means a maximum of 8 extra-strength or 12 regular-strength pills a day.

With long-term use, NSAIDs can cause gastrointestinal (GI) problems. These problems range from upset stomach to ulcers to GI bleeding. For minor stomach upset, eating some food or drinking some milk before you take an NSAID may help. Your risk of GI problems from NSAIDs goes up the higher the dose you take and the longer you take them. Drinking alcohol may increase this risk. Acetaminophen is much less likely than NSAIDs to cause GI problems.

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NCCAM Health Information


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EditText of this page (last edited January 15, 2008)