Why is this medication prescribed?

Pemetrexed is used with another chemotherapy (anti-cancer) medication to treat malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity). Pemetrexed is also used to treat non-small cell lung cancer. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help cancer cells multiply.

How should this medicine be used?

Pemetrexed comes as a solution (liquid) to be injected into a vein. Pemetrexed is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.

Your doctor will probably tell you to take other medications, such as folic acid (a vitamin), vitamin B₁₂, and a corticosteroid such as dexamethasone (Decadron) to decrease some of the side effects of this medication. Your doctor will give you directions for taking these medications. Follow your doctor's directions carefully. Ask your doctor or pharmacist to explain any part you do not understand. If you miss a dose of one of these medications, call your doctor.

Your doctor will ask you to have regular blood tests before and during treatment with pemetrexed. Your doctor may change your dose of pemetrexed or delay treatment based on the results of the blood tests.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

• rash
• sores and/or redness in the mouth or throat or on the lips
• unusual bleeding or bruising
• sore throat, fever, chills, cough or other signs of infection
• extreme tiredness
• weakness
• pale skin
• headache
• dizziness
• confusion
• fast heartbeat
• difficulty falling asleep or staying asleep

What other information should I know?   

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to pemetrexed.

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