Side Effects and Cautions

• St. John's wort may cause increased sensitivity to sunlight. Other side effects can include anxiety, dry mouth, dizziness, gastrointestinal symptoms, fatigue, headache, or sexual dysfunction.
• Research shows that St. John's wort interacts with some drugs. The herb affects the way the body processes or breaks down many drugs; in some cases, it may speed or slow a drug's breakdown. Drugs that can be affected include:
  • Indinavir and possibly other drugs used to control HIV infection
  • Irinotecan and possibly other drugs used to treat cancer
  • Cyclosporine, which prevents the body from rejecting transplanted organs
  • Digoxin, which strengthens heart muscle contractions
  • Warfarin and related anticoagulants
  • Birth control pills
  • Antidepressants
• When combined with certain antidepressants, St. John's wort may increase side effects such as nausea, anxiety, headache, and confusion.
• St. John's wort is not a proven therapy for depression. If depression is not adequately treated, it can become severe. Anyone who may have depression should see a health care provider. There are effective proven therapies available.
• It is important to inform your health care providers about any herb or dietary supplement. you are using, including St. John's wort. This helps to ensure safe and coordinated care.