First stage - Compensatory stage of Renal Insufficiency， Serum Creatinine (scr) 133—177umol/L. As the compensatory capacity of kidney is large, although the renal function may decrease in clinical, the capacity of metabolic products excretion, and balance of water and electrolyte regulation can still satisfy the normal requirement. There are no symptoms in clinical, and the renal function tests are within the normal range or only slightly abnormal.

　　Second stage - Decompensation stage of Renal Insufficiency (or called Azotemia stage of renal insufficiency), Serum Creatinine (Scr) 177-443 umol/L. The quantity of glomerulus sclerosis and fibrosis is increase, about 60%-75% damaged. When the kidney excretes the metabolic waste, there have been some obstacles. Serum Creatinine and urea nitrogen shows a little high or over the normal level. The patients will appear anemia, fatigue without strength, weight loss, and concentration problems, etc. but often escaping their notice. If there are conditions of water loss, infection and bleed, etc. the progression of chronic kidney disease will accelerate.

　　Third stage - kidney failure, Serum Creatinine (Scr) 443-707umol/L, glomerulosclerosis, renal tubules interstitial fibrosis, causing severe renal function damage, obvious anemia, nocturia increase, Serum Creatinine, urea nitrogen increase obviously, and acidosis often. During this stage, if the patients don’t take a systemic and normal treatment, the disease will develops into the end-stage kidney disease. Treating difficulty becomes even more challenging.

　　Fourth stage -  Uremia or end-stage Renal Insufficiency, Serum Creatinine (Scr)>707 umol/L. Glomerular damage is over 95%, showing severe clinical symptoms, such as nausea, vomit, decreased urine output, edema, malignant hypertension, severe anemia, itchy skin (pruritus), and urine odor in mouth, etc.