‘What is creatinine clearance rate?’ How much do you know about it? We will tell you something about creatinine clearance rate in this article.

　　What is creatinine clearance rate?

　　Creatinine clearance rate is also called endogenous creatinine clearance rate, the short term is CCr. The normal range of creatinine clearance rate is male 85—125ml/min, female 75—115ml/min. The decline of creatinine clearance rate is often seen in Renal Insufficiency and Uremia etc. It can reflect glomerular filtration function in some degree, that is glomerular filtration rate.

　　After kidney transplant, if the patient’s CCr is over 50, it is normal, and  the optimum is over 70. Some hospitals have taken the renal toxicity of cyclosporine into account, so if the CCr is over 45 and is stable, it is also normal.

　　The clinical significance of CCr:

　　1. CCr is less than 80% of the reference range suggests the decline of glomerular filtration function.

　　2. CCr is between 50～70 ml/min suggests slight damage of renal function.

　　3. CCr is between 31～50 ml/min suggests moderate damage of renal function.

　　4. CCr below 30ml/min suggests severe damage to renal function.

　　5. CCr low to 11～20ml/min is early stage Renal Failure.

　　6. CCr low to 6～10ml/min is early stage Uremia.

　　7. CCr less than 5ml/min is end stage Uremia.