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Wilson Disease Symptoms
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Is there any treatment?

WD requires lifelong treatment, generally using drugs to remove excess copper from the body and to prevent it from re-accumulating.  Zinc salt, which blocks the absorption of copper in the stomach and causes no serious side effects, is often considered the treatment of choice. Penicillamine and trientine increase urinary excretion of copper; however, both drugs can cause serious side effects.  Tetrathiomolybdate is an investigational drug with a lower toxic profile, but it has not been approved by the Food and Drug Administration for the treatment of WD and its long-term safety and effectiveness aren't known.  A low-copper diet may also be recommended, which involves avoiding mushrooms, nuts, chocolate, dried fruit, liver, and shellfish.  In rare cases where there is severe liver disease, a liver transplant may be needed.  Symptomatic treatment for symptoms of muscle spasm, stiffness, and tremor may include anticholinergics, tizanidine, baclofen, levodopa, or clonazepam.

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National Library of Medicine & Centers for Disease Control and Prevention (CDC)


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EditText of this page (last edited November 5, 2007)

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